Name: Napsin A Antibody-Clone MRQ-60
Description and aplications: Napsin is a pepsin-like aspartic proteinase, in the A1 group of the AA class of proteinases. There are two closely related napsins, napsin A and napsin B. Napsin A is expressed as a single chain protein with the molecular weight of approximately 38 kDa. Immunohistochemical studies revealed high expression levels of napsin A in human lung and kidney but low expression in spleen. Napsin A is expressed in type II pneumocytes and in adenocarcinomas of lung. The high specificity expression of napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of other organs. Napsin A is also useful for the study of renal papillary adenocarcinomas and clear cell adenocarcinomas as it might be positive in high percentage of the cases. Conversely it is expressed by less than 5% of papillary carcinomas of the thyroid.
Composition: anti-Napsin A mouse monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal.