Name: Antibody (Polyclonal) OSTEOCALCIN (FL-100)
Description and applications: Bone γ carboxyglutamic acid (Gla) protein, known as BGLAP, BGP or osteocalcin, is an abundant, non-collagenous protein component of bone that is produced by osteoblasts. In mice, osteocalcin is composed of a cluster of three genes known as OG1, OG2 and ORG, all of which can be found within a 23 kb span of genomic DNA. Human osteocalcin is a highly conserved, 46-50 amino acid, single chain protein that contains three vitamin K-dependent γcarboxyglutamic acid residues. Osteocalcin appears transiently in embryonic bone at the time of mineral deposition, where it binds to hydroxyapatite in a calcium-dependent manner. In addition, osteocalcin is one of the most abundant, non-collagenous proteinsfound in mineralized adult bone. Genetic variation at the osteocalcin locus on chromosome 1q impacts postmenopause bone mineral density (BMD) levels and may predispose some women to osteoporosis.
Composition: Anti-human Osteocalcin rabbit polyclonal antibody purified from serum and prepared in PBS with < 0.1% sodium azide and 0.1% gelatin.
IMMUNOGEN: antibody raised against amino acids 1-100 representing full length osteocalcin of human origin.