آنتی بادی Cytokeratin 18 کلون MX035 برند Patho Sage

Specification:

Cytokeratin’s (epithelial keratins) are an important component of the intermediate filament system. They are mainly insoluble molecules playing an important role in cellular mechanics. There are two types of cytokeratin’s: a) type I: (9-20) keratins that are relatively acidic and bearing a small molecular weight (40-56.5 kDa) and b) type II: (1-8) that are relatively basic-neutral of larger molecular weight (53-67 kDa). Proliferating cells have a substantial pool of two soluble cytokeratin’s, namely CK8 and CK18 and their concentration is high during the G2-M phase of the cell cycle. During apoptosis, CK18 are cleaved by caspases at position Asp396 producing relatively stable fragments.

Presentation:

Tissue culture supernatant containing 15mM sodium azide