Specification:
Monoclonal antibody Lu-5 reacts with an epitope which is common to all cytokeratins respectively with a cytokeratin associated protein. The antigen recognized by anti-cytokeratin pan is present in all types of epithelia. It recognizes most subtypes of cytokeratins in cryofixed and paraffin sections and is ideally suited as a first order pan-epithelial marker. The epitope recognized by Lu-5 is a formalin-resistant marker of great value in tumor diagnosis, located on the surface of cytokeratin filaments. It has been preserved during vertebrate evolution and can be shown in all species from amphibia to man. The epitope is present in most cytokeratin polypeptides of both the acidic (type I) and basic (type II) subfamily but does not occur in other cytoskeletal proteins. The epithelial specificity and the broad tissue and species cross reactivity provide an excellent probe for the differential diagnosis of epithelial versus mesenchymal tumors, large cell lymphomas and neural tumors.
Immunogen:
Lung tumor cell lines A549 and A2182
Presentation:
Concentrated cell culture supernatant in phosphate buffered saline pH 7.2 (PBS), and 0.05% sodium azide as a preservative
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