آنتی بادی MLH1 کلون ES05 برند Patho Sage

Specification:

MLH1, a mismatch repair protein involved in maintaining the integrity of genetic information, alongside MSH2, MSH6 and PMS2. During DNA replication, strand misalignment can occur resulting in alterations to microsatellite repeats, often referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been linked to human carcinogenesis. Mutations in the MLH1 gene have been reported to be found in tumors with MSI, such as some forms of colon cancer e.g. Hereditary nonpolyposis colon cancer (HNPCC), a subset of sporadic carcinomas and breast cancer. Loss of expression of MLH1 has also been reported in acute lymphoblastic leukemia, endometrial carcinoma, gastric carcinoma and ovarian carcinoma.

Immunogen:

Prokaryotic recombinant protein corresponding to 210 amino acids of human MLH1

Presentation:

purified immunoglobulin fraction diluted in PBS with 1% BSA containing 15 mM sodium azide as a preservative