Specification:
The p63 gene is located at chromosome 3q27-29 and belongs to the p53 gene family. p63 plays a critical role in the growth and development of many epithelial organs. p63 is confined to basal cells of squamous epithelia (including epidermis and hair follicles) and urothelium, as well as basal cells/myoepithelial cells in breast, sweat glands, salivary glands, and prostate. The expression of p63 has clinical value as a diagnostic marker in various tumor types. Thus, p63 helps to distinguish squamous cell carcinoma from adenocarcinoma in the lung or urothelial carcinoma from renal cell carcinoma. As known marker of basal cells in breast and prostate, p63 expression is useful for prostate cancer diagnosis and identifies a basal phenotype in some breast carcinomas.
Presentation:
tissue culture supernatant with 15mM sodium azide
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