Specification:
This antibody is designed for the specific localization of bcl-2 protein in formalin-fixed, paraffin-embedded tissue sections. It is intended for in vitro diagnostic use. Clone 100/D5 reacts with bcl-2 alpha oncoprotein as assessed by reaction with a 26-kD band in immunoblotting. This antibody stains the 380 cell line which carries a 14;18 chromosomal translocation. bcl-2 oncogene codes for two closely similar proteins, bcl-2 alpha and bcl-2 beta. These two proteins differ only in their carboxyl terminal sequences. bcl-2 is an integral inner mitochondrial membrane protein and is frequently overexpressed in many lymphoid malignancies. This protein also interferes with programmed cell death independent of promoting cell division. IHC staining for bcl-2 protein can be used to distinguish neoplastic germinal centers from reactive ones.
Immunogen:
A synthetic peptide, aa41-54 (GAAPAPGIFSSQPG-Cys) of human Bcl-2 protein
Presentation:
Bioreactor Concentrate with 0.05% Azide
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