Flocytometry Antibodies

FITC F(ab’)2 Goat anti-human IgG Fcγ Antibody

Company:BioLegend

Catalog Number: 398006

Size : 100 µg

Clone : Poly23980

Isotype : Goat Polyclonal Ig

Reactivity : Human

Description :

gG Fc is a homodimer that is composed of the constant region of the two heavy chains that form the IgG molecule. The Fc fragment mediates opsonization, antibody dependent cellular cytotoxicity (ADCC), and complement activation through binding to Fc receptors such as CD16, CD32, CD64, and the complement factor C1.

PE anti-human CD79a (Igα) Antibody

Company:BioLegend

Catalog Number : 333503

Size: 25 tests

Clone : HM47

Isotype : Mouse IgG1, κ

Reactivity: Human

Description:

CD79a is a 47 kD type I integral membrane protein, also known as mb-1 or Iga. It is a member of the Ig superfamily and disulphide-associated with CD79b (B29). The interaction of CD79a/CD79b heterodimer with B cell suface Ig forms B cell antigen complex. CD79a is expressed in B cells from early pre-B to plasma cell stage. It has been shown that CD79a is also weakly expressed in some precursors of T- and myeloid cells. CD79 mediates the transport of IgM to B cell surface and transduces signals initiated by BCR aggregation.

PE anti-mouse CD366 (Tim-3) Antibody

Company:BioLegend

Catalog Number : 119703

Size : 50 µg

Clone : RMT3-23

Isotype : Rat IgG2a, κ

Reactivity : Mouse

Description :

CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on Th1 lymphocytes and CD11b macrophages. Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

PE anti-TCF1 (TCF7) Antibody

Company:BioLegend

Catalog Number : 655208

Size : 100 tests

Clone : 7F11A10

Isotype : Mouse IgG1, κ

Reactivity : Human

Description :

TCF1 is the first identified member of the T-cell-specific transcription factor family. It plays an important role in T cell development and differentiation. TCF1 is inactivated by association with the transcriptional repressor TLE proteins. During Wnt signaling, the transcriptional coactivator CTNNB1 accumulates and, in turn, replaces the transcriptional repressor associated with TCF1. Interaction with CTNNB1 results in transactivation of TCF1 target genes. Deletion of TCF1 causes massive apoptosis of double positive thymocyte, suggesting that TCF1 is required for thymocyte survival during T cell development. In addition to its function in thymus, TCF1 promotes T cell differentiation to Th2 cells in the periphery through transcriptional activation of GATA3.

PE/Cyanine5 anti-human CD3 Antibody

Company:BioLegend

Clone: HIT3a

Isotype: Mouse IgG2a, κ

Cat Number: 300309

Reactivity: Human

Antibody Type: Monoclonal

Description:

CD3ε is a 20 kD chain of the CD3/T-cell receptor (TCR) complex which is composed of two CD3ε, one CD3γ, one CD3δ, one CD3ζ (CD247), and a T-cell receptor (α/β or γ/δ) heterodimer. It is found on all mature T lymphocytes, NK-T cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation.

PE/Cyanine5 anti-human CD19 Antibody

Company:BioLegend

Catalog Numbeer: 302209

Size : 25 tests

Clone : HIB19

Isotype: Mouse IgG1, κ

Reactivity: Human, Chimpanzee, Rhesus

Description :

CD19 is a 95 kD type I transmembrane glycoprotein also known as B4. It is a member of the immunoglobulin superfamily expressed on B-cells (from pro-B to blastoid B cells, absent on plasma cells) and follicular dendritic cells. CD19 is involved in B cell development, activation, and differentiation. CD19 forms a complex with CD21 (CR2) and CD81 (TAPA-1), and functions as a BCR coreceptor.