Name: Mouse Anti-Human Uroplakin II Monoclonal Antibody (Clone BC21)
Description and aplications: Uroplakin II (UP2) is a membrane-specialized protein of 15kDa that, along with the Uroplakins 1A, 1B and 3, compose the asymmetric membrane unit located in the apical cell plates of the human urothelium. UP2 is synthesized by urothelial cells in the final stage of differentiation. The synthesis of the protein is coded by the UPK2 gene located in the chromosome region 11q23.3. In normal tissues, the antibody specifically recognizes the UP2 in the surface layers of the normal urothelium, being negative in the rest of the human epithelia.
Composition: anti-Uroplakin 3 mouse monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal.
Immunogen: Residues corresponding to amino acids 3650 of the human Uroplakin II