Name:Cadherin 17 Antibody clone SP183
Description and applications: Cadherins represents a big family of Ca2+ dependent transmembrane cell adhesion glycoproteins that interact homophilically with each other and thus participate in the heterologous cell selection. They play a key role in the embryonic development and in the maintenance of the normal structure in adult tissues. Molecular defects in the structure of cadherins represent important pathogenic aspects of many diseases, including cancer. The cadherin 17 gene (CDH17) is located on the chromosome region 8q22.1 that encodes a protein of 832 amino acids and approximately 92kDa of molecular weight. Cadherin 17, also known as human peptide transporter 1 (HPT-1) or liver-intestine cadherin (LICadherin), is located in the lateral contact areas of the intestinal epithelial cells, being undetectable in the stomach, kidney, lung or liver, among other organs. It
features many structural similarities with the kidney specific cadherin, both belonging to the 7D-cadherin family. In tumors, the great specificity of cadherin 17 to identify the primary or metastatic colorectal adenocarcinomas has been demonstrated. Less frequently, cadNherin 17 has been described in gastroesophageal junction adenocarcinomas or adenocarcinomas with gastric origin. In the few available studies, cadherin 17 has shown staining in all well-differentiated neuroendocrine tumors (carcinoid tumors) originated in the small intestine and in the appendix. Up to 80% of the primary pancreatic adenocarcinomas and only half of their metastases are usually positive. Up to 50% of cholangiocarcinomas show membrane staining against cadherin 17, showing greater sensitivity than other markers such as villin, CDX2 or SATB2, which can be used to refine the diagnosis. Cadherin 17 shows along with SATB2 greater sensitivity in the detection of medullar carcinomas of the large intestine that are usually negative for CDX2 and cytokeratins 7 and 20.
Composition: Anti-human Cadherin 17 rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide