Name: CD19 Antibody (Clone MRQ-36)
Description and aplications: This antibody recognizes the CD19, a surface glycoprotein of 95 kD which is present in both malignant and normal B cells which was always been considered as the most reliable surface marker of this cell line, within all range of stages of maturation. In the normal lymphoid tissue, the CD19 staining appears in germinal centers (follicular dendritic cells and B cells) in the mantle zone and as scattered cells within the interfollicular areas with overlapping patterns of immunostaining with CD20 and CD22 cells. However, in contrast to CD20, CD19 is also expressed on pre-B cells. CD19 was detected by flow cytometry in extramedullary plasma cells isolated from human tissue. CD19 positivity appears in the vast majority of B cell neoplasms while the plasma cell neoplasms are always negative. No CD19 stain was detected in Reed- Sternberg cells of Hodgkin’s disease.
Composition: anti-CD19 mouse monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal.