پروب فیش DLEU1/TP53 FISH Probe

INTRODUCTION: The DLEU1 gene was originally identified as a potential tumor suppressor gene. The TP53 gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Rearrangements and abnormal expression of the DLEU1 gene region – also known as BCMS, DLB1, LEU1, LEU2, XTP6, BCMS1, DLEU2, LINC00021 or NCRNA00021 – and the TP53 gene – also known as P53, BCC7, LFS1 or TRP53– have been observed in B-cell chronic lymphocytic leukemia (CLL) and other malignancies.
INTENDED USE: The DLEU1/TP53 FISH Probe Kit is designed to detect the human DLEU1 and TP53 genes located on chromosome bands 13q14.2 and 17p13.1, respectively. Both probes are designed to measure the copy number of the human DLEU1 and TP53 genes located on chromosome bands 13q14.2 and 17p13.1, respectively.

PROBE DESCRIPTION: The DLEU1 Probe of the DLEU1/TP53 FISH Probe Kit labeled with the fluorochrome CytoOrange covers the center sequences and the 5′ (start) portion of the DLEU1 gene and some adjacent genomic sequences. The TP53 Probe of the DLEU1/TP53 FISH Probe Kit labeled with CytoGreen covers a chromosomal region which includes the entire TP53 gene.