.(Name: FoxP3 Antibody (Clone SP97
Description and aplications: FOX human protein family consists of at least 43 transcription factors, among which is the FoxP3 protein or Scurfin, whose gene is located on Xp11.23 chromosomal region. The proteins of this family are involved in a wide range of processes including control of cell proliferation and differentiation, immune regulation and signal transduction.. Foxp3 plays a very important role in the regulation of T cell activation and acts as transcriptional repressor transactivator suppressing cytokine genes by competition with the NF-AT / AP1 factor controlling the production of cytokines such as IL-2, IL-4, IFN-gamma, TNF-stimulating factor and granulocyte-macrophage colonies (GM-CSF). In addition to the important role that FOXP3 plays in regulating the immune response, recent studies have shown that this molecule can act as a tumor suppressor factor in intraepithelial neoplasia of the prostate, breast (especially in its triple negative variant) and ovarian among other. Generally, FOXP3 expression has dual character, meaning that usually some normal tissues with positive nuclear staining may develop negative tumors and, vice versa, when negative normal tissue occasionally produce positive tumors. This is the case for example of prostatic epithelium and mammary ducts where FOXP3 is expressed constitutively at nuclear level, or pancreatic ducts and melanocytes where staining is negative. In these tumors the presence of numerous positive cells is associated with a poorer response to chemotherapy.
Composition: anti-human FoxP3 rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Immunogen: Synthetic peptide corresponding to C-terminus of human FoxP3.