Name: Islet 1 Monoclonal Antibody clone EP283
Description and aplications: Islet-1, Insulin gene enhancer protein ISL-1, is a protein that in humans is encoded by the ISL1 gene. This gene encodes a transcription factor containing two N-terminal LIM domains and one C-terminal homeo domain. The encoded protein plays an important role in the embryogenesis of pancreatic islets of Langerhans. ISL1 has been shown to interact with Estrogen Receptor alpha. Islet-1 produces a strong nuclear staining in the islets of normal pancreas and tumor cells of the pancreatic neuroendocrine tumors. Islet-1 has been found to be a reliable marker of pancreatic endocrine tumors and metastasis. It shows a comparable sensitivity and specificity as CDX2 as a marker of ileal and appendiceal neuroendocrine tumors and their metastasis. A panel of Islet-1, CDX2 and TTF1 may be useful in differentiation well-differentiated endocrine carcinomas of unknown origin.
Composition: Anti-human Islet 1 rabbit monoclonal antibody purified from culture supernatant, filtered, sterilized and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide