Name: LH (Luteinizing Hormone) Antibody (Polyclonal)
Description and applications: This antibody reacts with the human luteinizing hormone (LH). The adenohypophysis produces six main hormones: prolactin (PRL), growth hormone (GH), adrenocorticotropic hormone (ACTH), thyroid stimulating hormone (TSH), follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The
producing cells (approximately 10%) of the two latest hormones are located in the pars tuberalis of the hypophysis. The glycoprotein hormones LH, FSH and TSH are heterodimers with a common alpha subunit and a solely beta subunit that gives a biochemical, immunological and functional specificity as hormone. The LH induces the secretion of sex steroids in the gonads of both sexes; the Leydig cells of the testicle respond synthesizing testosterone and in the ovary, the theca cells respond synthesizing estrogens and inducing ovulation. The luteinizing hormone (LH) is a glycoprotein secreted by both normal and neoplasic hypophysary cells. Therefore, it can be detected in hypophysary adenomas derived from these cells that correspond to chromophobe cells. They represent approximately 6% of hypophysary adenomas.
The LH/FSH secreting adenomas have a slow growth and, at the moment of the diagnosis, are usually large, although they are rarely associated with high serum levels of gonadotropins. The adenomas that only secrete LH are rare. The null cell adenomas and oncocytomas, that do not prove clinically nor biochemically hormone production, show focal expression of LH, FSH, TSH and alpha subunit.
Composition: anti-human LH (Luteinizing Hormone) rabbit polyclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and
0.09% sodium azide.
Immunogen: Purified luteinizing hormone from the human hypophysis.