Name: Mucin 2 (MUC-2) Antibody (Clone Ccp58)
Description and applications: Secreted epithelial mucins are large macromolecules which exhibit extreme polydispersity. Mucin 2 is the major intestinal mucin. O-glycans are attached to MUC2 in a potentially diverse arrangement, which is crucial for their interaction with endogeneous and exogeneous lectins. MUC2 is expressed in glandular epithelium (goblet cells) of normal small and large intestine, Barrett’s esophagus and breast glandular epithelium; it is not expressed in stomach or pancreas. In neoplastic tissues the pattern of mucins expression in tumours has been associated with tumor location, the biological aggressiveness and the infiltration capacity of certain malignancies. MUC2 is expressed by colon and appendix signet ring adenocarcinomas, breast colloid carcinoma, Paget’s disease of the breast and prostate carcinoma. It is not expresses by endometrial carcinomas, the non-mucinous breast or pancreatobiliary carcinomas.
Composition: anti-human MUC-2 mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.