Name: MSH6 Antibody (Clone EP49)
Description and aplications: The MutS homologue 6 protein (MSH6) is a member of the MutS homolog family required in the DNA match repair system.Carriers of the mismatch repair gene mutations have a high lifetime risk of developing Hereditary Non-Polyposis Colon Cancer (HNPCC) and several other cancers including endometrial cancer due to microsatellite instability (MSI) caused by accumulation of DNA replication errors in proliferating cells. MSH6 antibody is useful for screening and diagnosis of patients with MSI. The level of MSI has been reported to be associated with prognosis in colon cancer. Adding of PMS2 and MSH6 to MLH1 and MSH2 antibodies increased sensitivity for diagnosis of MSI. Tumors with low-level MSI show unfavourable pathological characteristics compared to tumours with no and tumours with high-level MSI.
Composition: anti-human MSH6 rabbit monoclonal antibody purified from ascites. Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
دیدگاهها
هیچ دیدگاهی برای این محصول نوشته نشده است.