آنتی ­بادی Myogenin (EP162)

Name: Myogenin-Clone EP162

Description and applications: acid-rich region and a helix-loop-helix (HLH) structure, which can promote muscle development and maintain muscle-specific gene expression by transactivation. Myogenin, one of the myogenic regulatory factors, plays a key role in determining the commitment and differentiation of primitive mesenchymal cells into skeletal muscle. The expression of Myogenin is restricted to cells of skeletal muscle origin, but it is not detected in adult skeletal muscles. It is therefore considered to be an extremely reliable and specific marker for diagnosing rhabdomyosarcomas. Myogenin is positive in virtually 100% of alveolar, sclerosing and botryoides rhabdomyosarcoma and in over 60% of pleomorphic rhabdomyosarcoma and is useful in recognizing adult spindle cell rhabdomyosarcomas. Less than 20% of Wilms tumors, congenital infantile fibrosarcoma, childhood myofibromatosis, synovial sarcoma and desmoid tumors have been reported positive. Ewing sarcoma, rhabdoid tumor, epithelioid sarcoma, leiomyosarcoma, miofibrosarcomas and nodular fasciitis show no reactivity to myogenin.

Composition:anti-human Myogenin rabbit monoclonal antibody purified by protein affinity and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

Immunogen: A synthetic peptide corresponding to residues in human Myogenin was used as an immunogen.