Specification:
β-Catenin is a 92 kDa protein that binds to the cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenin’s at adherens junctions (zonula adherens). Deletions in the cytoplasmic domain of E Cadherin which eliminate catenin binding also result in a loss of cell adhesion, indicating that this binding is essential for E Cadherin function. Although the α- and β-Catenin’s have been cloned, very little is known about their biochemical roles. However, a link between β-Catenin and colon cancer has been described. β-Catenin was found to co-immunoprecipitated with the APC tumor suppressor protein in human colorectal tumor cell lines, as well as in human kidney 293 cells. E-Cadherin, however, was not detectable in these complexes. Thus, the APC Catenin complex may be affecting the transmission of contact inhibition signals and/or the regulation of cell adhesion.
Immunogen:
Mouse β-Catenin aa. 571-781
Presentation:
0.05 mg/ml in Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
دیدگاهها
هیچ دیدگاهی برای این محصول نوشته نشده است.