آنتی بادی CD61 Intergrin Beta3 کلون YR/51 برند Patho Sage

Specification:

Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). It associates with the αV-chain (CD51) to form vitronectin receptor, or with the αIIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumors metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblast leukemia.

Presentation:

Purified antibody from Bioreactor concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% Azide.