Specification:
As one of the cyclin-dependent kinase inhibitors that inhibit cyclin-dependent kinases 4 and 6, p16 INK4A is encoded by tumor suppressor gene CDKN2A. The tumor suppressor p16 INK4A plays an important role in cell cycle regulation. Increased expression of the p16 gene, which is seen as organisms age, reduces the proliferation of stem cells. This reduction in the division and production of stem cells protects against cancer while increasing the risks associated with cellular senescence. Mutations in the p16 gene associated with loss or over expression of the protein are associated with increased risk of a wide range of cancers and cancer precursor lesions. The Immunohistochemical identification of p16 is particularly relevant in uterine cervical lesions: Development of dysplasia is closely related to human papilloma virus (HPV) infection.
Presentation:
Tissue culture supernatant containing 15mM sodium azide
دیدگاهها
هیچ دیدگاهی برای این محصول نوشته نشده است.