Name: TCL1 Antibody (Clone EP105)
Description and applications:T-cell leukemia/lymphoma protein 1A (TCL1) is a member of the TCL1 family and enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. TCL1 promotes the nuclear translocation of AKT1 and enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell
survival. The expression of TCL1 is restricted to lymphoid cells. It is expressed early in lymphocyte differentiation. Strong expression of TCL1 is fouma, follicular lymphoma, Burkitt lymphoma,diffuse large B-cell lymphoma (60%), and primary cutaneous B-cell lymphoma (55%). The expression of the TCL1 gene charactend in a subset of mantle zone B lymphocytes and is expressed to a lesser extent by follicle center cells. In B-cell neoplasia, TCL1 immunoreactivity is found in the majority of B-cell lymphomas including lymphoblastic lymphoma, chronic lymphocytic leukemia, mantle cell lymphorizes low-grade B-cell lymphomas.
Composition:Anti-human TCL1 rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
Immunogen:Synthetic peptide corresponding to residues in human TCL1 protein.