آنتی ­بادی Villin-1 (CWWB1)

.(Name: Villin-1 Antibody (Clone CWWB1

Description and applications:Villin is a tissue-specific protein with a molecular massAnti-villin monoclonal antibody (CWWB1 clone) against the human antigen has a sensitivity of almost 100% and high specificity; thus, immunostaining is fully reproducible using standard amplification and development procedures performed as part of automated immunostaining systems. Villin is expressed in the brush border of enterocytes and kidney proximal tubule cells. In addition to allowing immunohistochemical identification of villin in normal human tissues, this antibody is a highly specific marker of gastrointestinal tumours and pancreatic cancer. Although with less sensitivity, renal, hepatic and pulmonary neoplasms, especially carcinoid tumours, neuroendocrine tumours and signet-ring cell carcinomas or carcinomas with microlumens filled with microvilli, as well as some breast and ovarian tumours, are also stained. of 95.5 kDa. Of all proteins belonging to the gelsolin family, it is the only one capable of assembling and disassembling actin filaments through three specific binding domains, two of them Ca2+-dependent. Villin is essential for the assembling of the cell brush border citoskeleton and the organization of the actin filament bundle forming the core of microvilli. In addition, it has been proposed that this protein, due to its dependence on cell activation via phosphatidylinositol, is essential for the control of cell polarity during embryonic development of tissues containing it, as well as to facilitate epithelial plasticity in response to cell injury and immune system cell elements migration through the intestinal barrier.

Composition:Anti-human Villin-1 mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

Immunogen:uman villin protein.