| Clone | QR012 |
|---|---|
| REF | C-C003 |
| Dilution | 1:100 – 1:200 |
| Immunogen | Synthetic peptide of human CD117 |
| Isotype | IgG |
| Species of origin | Rabbit |
CD117, also known as c-Kit, encodes a receptor tyrosine kinase that is activated by its ligand stem cell factor (also known as mast cell growth factor). CD117 plays an important role in vital functions, such as homeostasis and melanogenesis. In normal tissues, expression is found in interstitial cells of Cajal, mast cells, melanocytes, various epithelia, testicular and ovarian interstitial cells, neurons of the central nervous system, immature myeloid cells, trophoblastic cells, fetal (but not mature) endothelial cells and fetal (but not mature) basal cells of the skin. CD117 does not occur in smooth muscle cells.
CD117 is a proto-oncogene. Mutations and overexpression are associated with several cancer types, including gastrointestinal stromal tumors (GIST) with 80 95% expression and seminoma with > 90% expression.
CD117 is expressed in around 15-30% of melanomas, although this can vary depending on the type of melanoma. About 30% of lung adenocarcinoma show expression of CD117.
