آنتی بادی CD3e کلون QR004 برند Quartett

CD3 is a protein complex that is composed of five chains (gamma, delta, epsilon, zeta, eta) which associate with theT-cell receptor (TCR). CD3 is first expressed in the cytoplasm of developing T-cells, then as they mature it moves to the membrane. CD3e is a membrane protein that plays a role in TCR-CD3 complex assembly and signal transduction regulating T-cell proliferation, apoptosis and thymocyte development. CD3e immunostaining is only seen in T-cells. These predominantly occur in lymphatic organs such as thymus, lymph nodes and tonsils but are regularly also seen – at lower density – in many other tissue types. In malignant lymphomas, CD3 is a pan-T-cell lineage-restricted antigen, detected in 72-95% of the T-cell lymphomas. As B-cell lymphomas are mostly negative forCD3e, the antibody can be used to distinguish between T-cell and B-cell lymphomas.