| Clone | QR092 |
|---|---|
| REF | C-I005 |
| Dilution | 1:100 – 1:200 |
| Immunogen | Synthetic peptide of human IgG4 |
| Isotype | IgG |
| Species of origin | Rabbit |
Immunoglobulin G is the most abundant antibody isotype found in the circulation. Human IgG4, one of four subclasses of IgG, contains a gamma 4 heavy chain and a hinge region that is shorter than that of IgG1. The two primary effector functions are activating complements and binding to the FcgR of effector cells to initiate phagocytosis. Human IgG4 accounts for less than 6 % of the total IgG serum level. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lympho-plasmacytic infiltration with the presence of many IgG4-positive plasma cells. IgG4 is overexpressed in inflammatory pseudo-tumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). In pulmonary nodular lymphoid hyperplasia (PNLH), there are an increased number of IgG4+ plasma cells.
