| Clone | QR008 |
|---|---|
| REF | C-T004 |
| Dilution | 1:50 – 1:200 |
| Immunogen | Synthetic peptide of human pan-TRK |
| Isotype | IgG |
| Species of origin | Rabbit |
Pan-TRK is a marker for the proteins Trk A, B and C. Neurotrophic tyrosine kinase receptor (NTRK) is a family of 3 proto-oncogenes including NTRK1, NTRK2, and NTRK3 which encode Trk A, Trk B, and Trk C proteins, respectively. The latter are involved in biological processes such as neuronal survival, differentiation, and plasticity under physiological circumstances. In various cancers, oncogenic fusions involving the kinase domain of NTRK1, 2, or 3 are present. Recently, detecting NTRK fusions has become increasingly important as Trk inhibitors have a high response rate for patients with NTRK fusions. Specific staining patterns appear to correlate with the subcellular localization of the fusion partners.
