| Clone | QR014 |
|---|---|
| REF | C-P006 |
| Dilution | 1:100 – 1:200 |
| Immunogen | Synthetic peptide of human Progesterone receptor |
| Isotype | IgG |
| Species of origin | Rabbit |
Progesterone receptor (PR) is a nuclear hormone receptor that activates transcription of various genes, especially in reproductive tissues, regulated by its ligand progesterone. PR is predominantly expressed in female sex steroid responsive tissues such as the mammary gland, uterus and ovary. Two isoforms exist: PR-A (94 kDa) and PR-B (114 kDa). Ratio of these isoforms varies in reproductive tissues and during carcinogenesis. PR is expressed in about 65-75% of breast carcinomas. The expression of PR is usually closely linked to the expression of the estrogen receptor (ER), as both receptors are hormonally regulated. PR-positive status is often used as an indicator for a better prognosis and a better response to hormone therapies.
