آنتی بادی Human C1q (Polyclonal) -FITC

Anti-Human C1q

DESCRIPTION AND APPLICATIONS :C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

C1q is predominantly produced by macrophages but also by follicular dendritic cells, interdigitating cells and cells of the monocyte-macrophage lineage. C1q deficiency has a profound effect on host defence and clearance of immune complexes. Absence of C1q may cause autoimmunity by impairment of the clearance of apoptotic cells. Inherited C1q deficiency is also associated with the development of systemic lupus erythematosus (SLE).

This antibody should be used in conjunction with a panel of antibodies to aid in the identification of C1q fragment in target tissue (e.g., in the diagnosis of renal or dermal pathologies).

The interpretation of the results should be always corroborated with those of external controls and integrated with the morphological and clinical aspects for the final diagnosis

COMPOSITION: Anti-human Sheep Antibody to C1q. Fluorescein Conjugated Polyclonal antibody purified from serum and prepared in buffer with carrier protein and preservative for stabilization.

IMMUNOGEN: Human C1q, purified from plasma