Name: CD11b (Integrin Alpha-M) Antibody (Clone EP45)
Description and applications: Integrin alpha-M (ITAM, ITGAM, CD11b, Mac-1 alpha subunit, C3 alpha chain) is the alpha subunit of the ITAM/beta-2 complex, also named CD11b/CD18 or Mac-1, a leukocyte adhesion heterodimeric glycoprotein. CD11b is involved in monocyte, macrophage, and granulocyte adhesion. CD11b is mainly expressed in myeloid cells of human origin, NK1 cells, monocytes, and granulocytes. In neoplasms, CD11b is useful for the identification of acute myeloid leukaemias (AML) (AML with inv(16) or t(16;16), AML with 11q23/MLL abnormalities, myeloblastic AML with minimal differentiation, myelomonocytic AML, acute monoblastic leukaemia, and acute monocytic leukaemia), where blasts may express CD11b among other molecules of monocytic differentiation. CD11b is also expressed in T-cell large granular lymphocyte leukaemias and in aggressive NKcell leukaemias.
Composition: Anti-human CD11b (Integrin Alpha-M) rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.