Name: Mouse Anti-CD20 Monoclonal Antibody clone L26
Description and aplications: CD20 is a non-Ig differentiation antigen of B cells and the expression of CD20 is restricted to normal and neoplastic B cells, being absent from all other leukocytes and tissues. It acts as calcium channel involved in B cell activation and cell cycle progression. The antibody is useful for identifying B cell lymphoid malignancies, whether non-Hodgkin lymphoma, acute or chronic B lymphocytic leukemias and hairy cell leukemia. Also, the anti-CD20 antibody stains the tumor cells of Hodgkin’s disease nodular lymphocytepredominant subtype and occasionally, the Reed- Sternberg cells of other histologic variants of classic Hodgkin’s disease.
Composition: anti-CD20 mouse monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal.
Immunogen: Human tonsil B cells.