Name: CD41/Integrin alpha II b Antibody Clone EP178
Description and applications: CD41, also named GP IIb, is a protein that in human is encoded by the ITGA2B gene. This protein can be associated with GPIIIa to form a heterodimer complex (GPIIb-IIIa) in the presence of Ca2+. This complex can bind one of four different adhesive proteins (ie,fibrinogen,fibronectin, von Willebrand factor or vitronectin). CD41 expression has been found on platelets, megakaryocytes, and, more recently, on immature hematopoietic progenitors. CD41 is a reliable marker of early steps of hematopoiesis during embryonal stem cells differentiation. CD41 has been used as a marker for megakaryocytic differentiation.
Composition: anti-human CD41 rabbit monoclonal antibody purified from ascites. Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.