Name: CD95 Monoclonal Antibody clone EP2083
Description and aplications: The CD95 (Fas) protein is a cell surface receptor belonging to the tumor necrosis factor (TNF) family that transduces death signaling on engagement by multimeric Fas ligand (CD95L), of which there are eight in its membrane–bound form or in its soluble form resulting from cleavage by a putative metalloproteinase. CD95 is a widely expressed protein. CD95-mediated apoptosis is an essential mechanism for the maintenance of normal tissue homeostasis, and disruption of this death pathway has been associated with a wide range of human diseases, including autoimmune diseases, lymphoproliferative disorders and malignancies. The Fas death system also plays important roles in various apoptosis conditions such as those evoked by irradiation, chemotherapeutic
agents and viral infections. The expression of CD95 serves as a prognostic marker in predicting the outcome of disease progression and treatment in many types of tumors.
Composition: Anti-human CD95 rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide