Name: CXCL13 Antibody (Polyclonal)
Description and applications: CXCL13, also known as B lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. BCA1 cDNA encodes a protein of 109 amino acid residues with a leader sequence of 22 residues. Mature human BCA1 shares 64% amino acid sequence similarity with the mouse protein and 23-34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein coupled receptor originally isolated from Burkitt’s lymphoma cells, has now been shown to be the specific receptor for BCA1. Among cells of the hematopoietic lineages, the expression of BLR1, now designated CXCR5, is restricted to B lymphocytes and a subpopulation of T helper memory cells. Mice lacking BLR1 have been shown to lack inguinal lymph nodes. These mice were also found to have impaired development of Peyer’s patches and defective formation of primary follicles and germinal centers in the spleen as a result of the inability of B lymphocytes to migrate into B cell areas. The CXCL13 expression in angioimmunoblastic T-cell lymphoma contribute in their diagnostic.
Composition: anti-human CXCL13 goat monoclonal antibody antigen affinity-purified. Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
Immunogen: E. coli derived recombinant human CXCL13/BCA1 Val23Arg94