INTRODUCTION: Deletions and other abnormalities of the regions 1p and 19q have been observed in gliomas, astrocytomas, and other malignant diseases. The detection of the 1p/19q co-deletions represents a diagnostic criterion for oligodendrogliomas.
INTENDED USE: The FISH 1p36/1q25 probe is designed to simultaneously detect changes in the human TP73 and ABL2 genes, located in the 1p36.32 and 1q25.2 chromosome bands, respectively.
PROBE DESCRIPTION: The 1p36 FISH probe labeled with the CytoOrange fluorochrome covers a chromosome region that includes the whole TP73 gene located in the telomere region of the short arm of chromosome 1 and represents the target signal. The 1q25 FISH probe labeled with the CytoGreen fluorochrome covers a chromosome region that includes the whole ABL2 gene.
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