Name: Rabbit Anti-c-erbB2 Monoclonal Antibody clone SP3
Description and applications: C-erbB-2 is a receptor tyrosine kinase of the c-erbB family. The C-erbB-2 is a proto-oncogene located on human chromosome 17, band 21. It has structural similarities to the EGFR (Epidermal Growth Factor Receptor). Immunohistochemical staining of the oncoprotein is related to gene amplification. Different studies have demonstrated immunohistochemical detectable levels in more than 20% of adenocarcinomas of different locations, including ovarian, gastro-intestinal tract and breast. In the case of breast cancer, the overexpression has been shown to be associated with poor prognosis. This antibody is recommended to determine the expression levels of the oncoprotein C-erb B-2 in breast adenocarcinomas and other locations.
Composition: anti-cerbB2 rabbit monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal. Intended use : Immunohistochemistry (IHC) on paraffin embedded tissues. Not tested on frozen tissues or Western-Blotting
Immunogen: Recombinant protein encoding extracellular domain of human c-erbB2
Species reactivity: In vitro diagnostics in humans. Not tested in other species