Name: Mouse anti-human INSM1 (Insulinoma-associated protein 1) Monoclonal Antibody (Clone A-8)
Description and aplications: INSM1 protein, also known as IA1, is a nuclear transcription factor encoded by INSM1 gene, located in the chromosome region 20p11.23 and composed of 510 amino acids with a molecular mass of approximately 52.8kDa. The protein, which shows a wide homology in different species, contains a Cterminal portion with 5 finger-binding domains and an N-terminal domain with four pro-hormone conversion sites as well as an amidation signal sequence. INSM1 factor plays an important role in neurogenesis and differentiation during the embryonic and fetal development of the pancreatic neuroendocrine, anterior pituitary, intestine cells and synapto-adrenal cells of the peripheral nervous system. INSM1 gene, which does not express in normal endocrine and non-endocrine tissues in adults, acts as a suppressor gene of the transmission pathways NEUROD1 and INS after interaction with Cyclin D1, inhibits the specific genes of the skeletal muscle in neuroendocrine cells of the pituitary and suppress neural factors such as HDAC1, HDAC2, HDAC3 and KDM1A (involved in the incorporation of chromatin-modifying factors). In addition to this, it suppresses the activity of the histone deacetylase RCOR1.
Composition: Anti-human INSM1 mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH
7.4, with 0.2% BSA and 0.09% sodium azide