Name: Mesothelin Antibody Clone EP140
Description and aplications: Mesothelin gene encodes a 69 kDa precursor protein that progress to a protein of 40-kDa bound to a glycosylphosphatidylinositol (GPI), the mature mesothelin, present on the cell surface. Its biological function is not well understood, but recent studies have shown it forms a strong and specific complex with the MUC16, a union that has been suggested as the basis of ovarian cancer metastasis. Mesothelin is present on the surface of normal mesothelium that coats the pleura, peritoneum and pericardium. Mesothelin is overexpressed in patients with epithelial ovarian carcinoma and malignant mesotheliomas and may be useful to distinguish mesothelioma from other solid tumors. Its overexpression has been observed in other tumors too, including pancreatic carcinomas and cholangiocarcinoma.
Composition: anti-human Mesothelin rabbit monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal.
Immunogen: A synthetic peptide corresponding to residues at the C-terminus of human Mesothelin protein