Specification:
Bcl-6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein. Antibodies to this protein stain the germinal center cells in lymphoid follicles, the follicular cells and interfollicular cells in Follicular Lymphoma, Diffuse Large B-Cell Lymphomas, and Burkitt’s lymphoma, and most of the Reed-Sternberg cells in Nodular Lymphocyte Predominant Hodgkin’s Disease. In contrast, anti-BCL6 rarely stains Mantle Cell Lymphoma and MALT Lymphoma. BCL6 expression is seen in approximately 45% of CD30+ Anaplastic Large Cell Lymphomas but is consistently absent in other peripheral T-cell lymphomas.
Immunogen:
Recombinant BCL-6 protein
Presentation:
Bioreactor Concentrate with 0.05% Azide
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