Name:Synaptophysin Antibody (Clone EP158)
Description and applications: Synaptophysin is a major integral transmembrane glycoprotein of synaptic vesicles with four transmembrane domains. This protein is present in almost all neurons and neuroendocrine cells throughout the body. An antibody to Synaptophysin is useful for the identification of tumors with neural and
neuroendocrine differentiation. In well-differentiated tumors containing neurons (gangliocytoma, ganglioglioma, neurocytoma, ganglioneuroblastoma) synaptophysin is consistently expressed. Primitive neuroectodermal tumors (PNET) (cerebral PNET, medulloblastoma, neuroblastoma) show less intensity and variable reactivity.
Composition: anti-human Synaptophysin rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
Immunogen: A synthetic peptide corresponding to residues on the C-terminus (cytoplasmic domain) of human Synaptophysin protein.