Name: Treponema Pallidum Antibody (Polyclonal)
Description and applications: The antitreponema antibody included in this test consists of a purified fraction of rabbit IgG and is highly specific for the determination of spirochetes. With the increasing incidence of human immunodeficiency virus (HIV) infection and immunosuppressive therapy in various pathologies, the incidence of syphilis is growing in many parts of the world. Lesions that develop during secondary syphilis are difficult to diagnose clinically and they may even be accompanied by a negative serology. Likewise, the histopathological changes observed in these cases do not always meet the typical diagnostic criteria. Classically, spirochetes location was performed using silver impregnations such as Steiner and/or Warthin- Starry. Nevertheless, the identification of Treponema pallidum can now be successfully performed using immunohistochemical techniques on formalin-fixedparaffin-embedded tissues. In this sense, several studies have shown that these procedures, due to their greater sensitivity and specificity, offer significant advantages over traditional silver impregnations. This antibody displays cross-reactivity with Borrelia burgdorferi.
Composition: anti-human Treponema Pallidum rabbit polyclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
Immunogen: Treponema pallidum.