| Clone | QR055 |
|---|---|
| REF | C-N003 |
| Dilution | 1:100 – 1:200 |
| Immunogen | Synthetic peptide of human NKX3.1 |
| Isotype | IgG |
| Species of origin | Rabbit |
NKX3.1 is a transcription factor that acts as a putative prostate tumor suppressor. It is largely expressed in a prostate and androgen-regulated manner. NKX3.1 is expressed in normal prostate epithelium. Loss of the protein is a common finding in human prostate cancer and intraepithelial prostate neoplasia. The antibody NKX3.1 is a highly sensitive and specific marker for prostate adenocarcinoma and is useful in a panel with other prostate markers such as PSA, PSAP or Prostein, particularly in the case of low-differentiation tumors in which PSA, PSAP and / or Prostein are poorly expressed or can be lost. Primary and metastatic prostate carcinoma show a lower NKX3.1 staining intensity than the normal prostate.
