| Clone | QR041 |
|---|---|
| REF | C-S006 |
| Dilution | 1:100 – 1:200 |
| Immunogen | Synthetic peptide of human STAT6 |
| Isotype | IgG |
| Species of origin | Rabbit |
STAT family consists of seven genes, STAT1 to STAT4, STAT5A, STAT5B and STAT6, that are involved in regulating cellular proliferation, apoptosis, angiogenesis and the immune system response. STAT6 is a transcription factor that carries out a dual function: signal transduction and activation of transcription. It is involved in interleukin-4 signaling and seems to play an important role in cancer. STAT6 has been found to form recurrent fusions with NAB2 on chromosome 12q13 in the majority of solitary fibrous tumors (SFTs) excluding meningiomas, hemangioblastomas, schwannomas, and hemangiomas. The fusion enables cytosolic STAT6 to migrate to the nucleus. The detection of nuclear relocation of STAT6 with immunohistochemistry is a characteristic of SFTs and may serve as a diagnostic marker that indicates NAB2 STAT6 fusion.
