| Clone | QR097 |
|---|---|
| REF | C-V001 |
| Dilution | 1:100 – 1:200 |
| Immunogen | Synthetic peptide of human Vimentin |
| Isotype | IgG |
| Species of origin | Rabbit |
Vimentin is a type III intermediate filament protein and part of the cytoskeleton structure. The protein is expressed in mesenchymal cells and in a variety of tumors and cultured cells. It is also expressed in many cells during development. Vimentin plays an important role of cytoskeletal stability and cell integrity. During mitosis Vimentin is phosphorylated by several kinases like Auroa B, Rho-kinases or Cdk1. The antibody is a marker of mesenchymal cells. It can be used in combination with a panel of antibodies to detect tumors with mesenchymal origin and malignant melanoma. Tumors like lymphomas and seminomas have the same intermediate filament profile, but the vimentin expression is usually weaker.
