Name: Anti-Mucin 6 (MUC6) Antibody (Clone MRQ-20)
Description and aplications: Mucins are high molecular weight glycoproteins produced by epithelial cells. In humans, at least 14 genes encoding mucin has been identified (MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6, MUC7, MUC8, MUC9, MUC11, MUC12, MUC13 and MUC16). Mucins are classified as membrane associated (MUC1, MUC3, MUC4, MUC12 and MUC16), secreted mucins forming gels (MUC2, MUC5AC, MUC5B, and MUC6), or soluble secreted mucin (MUC7). Mucins are the major component of the mucus layer which protects against chemical and mechanical gastric mucosa aggression. MUC6 is expressed in the normal gastric epithelium of the pyloric antrum, in Brüner duodenal glands, small intestine, and pancreas; MUC6 is not expressed in ducts or acini of normal breasts or Barrett’s esophagus. In neoplastic tissues MUC6 is expressed in colloidal breast carcinomas. Breast carcinomas, pancreatic adenocarcinomas and cholangiocarcinomas do not express MUC6. The pattern of mucin expression in tumors has been associated with tumor location, the biological aggressiveness, and the infiltration capacity of certain malignancies.
Composition: anti-MUC-6 mouse monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal.