Name: CD7 Antibody-Clone-EP13
Description and aplications: This antibody recognizes a glycoprotein of 40kD molecular weight known as CD7 (also known as TP40 and Leu9). CD7 is positioned at 17q25.2-q25.3 and present on thymocytes, mature T cells, and NK cells. During T cell differentiation, CD7 is one of the earliest lineage markers to appear, therefore, the marker is considered the most clinically useful for acute lymphoid leukemia of T origin. In contrast, the CD7 molecule is absent in some cases as severe combined immunodeficiency. As the CD7 antigen is expressed in mature and immature T cells and NK cells, including those with mixed immuophenotype myeloid (precursor NK/myeloid cells leukemia), the anti-CD7 antibody is useful for the identification of lymphoid neoplasms derived therefrom. However it should be noted that in the peripheral T-cell lymphomas, frequent deletion or pre- and post-transcriptional regulation can lead to the loss of CD7 expression in the cell membrane, therefore their absence in this case does not rule out the origin of the T neoplasia. It is also not unusual in benign inflammatory dermatoses that reactive T cells do not express CD7, therefore, these histopathological features must be considered in the differential diagnosis.
Composition: anti-CD7 rabbit monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal.
Immunogen: A synthetic peptide corresponding to residues of human CD7 protein.