Name: Mammaglobin Antibodies (Clones 304-1A5 & 31A5)
Description and applications: Mamoglobina is a 10 kDa glycoprotein associated to the breast and relacionada with the family of secretoglobinas which include uteroglobin and lipophilin. Mammaglobin is encoded by the gene MGB1 located on chromosome 11q12.3-q13. This chromosome is frequently amplified in breast carcinomas. As compared to normal breast more than 23% of primary breast carcinomas and 62% the metastases overexpress mammaglobin. Overexpression does not seem to be related to histology, hormone receptor expression, grade or tumor stage. Other tumors with focal or diffuse mammaglobin expression are endometrioid adenocarcinoma, cervical adenocarcinoma, salivary gland tumors, sweat gland tumors and some melanomas. Head and neck, thyroid, lung (adenocarcinoma, squamous), stomach, colon, pancreatic and ovarian tumors do not express mammaglobin. Compared to GCDFP-15, Mammaglobin has demonstrated higher sensitivity for identifying primary and metastatic breast tumors.
Composition: cocktail of anti-Mammaglobin antibodies obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal.
