Name: Epithelial Membrane Antigen(EMA)-CloneE29
Description and applications: Anti-EMA antibody is a useful marker for staining many carcinomas. It stains normal and neoplastic cells from various tissues, including mammary epithelium, sweat glands and squamous epithelium. Hepatocellular carcinoma, adrenal carcinoma and embryonal carcinomas are consistently EMA negative, so keratin positivity with negative EMA favours one of these tumours. EMA is frequently positive in meningioma, which can be useful when distinguishing it from other intracranial neoplasms, e.g. Schwannomas. The absence of EMA can also be of value since negative EMA staining is characteristic of some tumours including adrenal carcinoma, seminomas, paraganglioma and hepatoma. Many mesotheliomas, epithelioid and synovial sarcomas, chordomas, choroid plexus tumors, nodular lymphocyte-predominant Hodgkin lymphoma, anaplastic CD30 / ALK positive lymphomas and myelomas are positive; occasionally some small round cell tumours and small cell sarcomas, T null phenotype or CD56 / CD57 + T / NK lymphomas are positive. Other lymphomas, basal cell carcinomas, hepatocellular carcinomas, melanomas, endocrine neoplasms and soft tissue tumours are consistently negative.
Composition: anti-human EMA mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.