INTRODUCTION: Deletions and other abnormalities of the regions 1p and 19q have been described in gliomas, astrocytomas, and other malignant diseases. The 1p/19q co-deletions represent a diagnostic criterion in the case of oligodendrogliomas.
INTENDED USE: The FISH 19q13/19p13 is designed to simultaneously detect changes in the human GLTSCR1 and ZNF443 genes, located in the 19q13.33 and 19p13.2 chromosome bands, respectively.
PROBE DESCRIPTION: The 19q13 FISH probe labeled with the CytoOrange fluorochrome covers a chromosome region that includes the whole GLTSCR1 gene in the telomere region of the long arm of chromosome 19 and represents the target signal.The 19p13 FISH probe labeled with the CytoGreen fluorochrome covers a chromosome region that includes the whole ZNF443 gene.
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