INTRODUCTION: Abnormalities in ATM – also known as AT1, ATA, ATC, ATD, ATE, ATDC, TEL1 or TELO1 – occur in ataxia telangiectasia, and have also been observed in chronic lymphocytic leukemia (CLL) and other malignancies. The GLI1 gene – also called GLI – is an oncogene that is expressed and sometimes amplified in several human cancers.
INTENDED USE: The ATM/GLI1 FISH Probe Kit is designed to detect rearrangements involving the human ATM and GLI1 genes located on chromosome bands 11q22.3 and 12q13.3, respectively.
PROBE DESCRIPTION:The ATM Probe of the ATM/GLI FISH Probe kit labeled with the fluorochrome CytoOrange covers a chromosomal region which includes the entire ATM gene. The GLI Probe of the ATM/GLI FISH Probe Kit labeled with CytoGreen covers a chromosomal region which includes the entire GLI1 gene. Both probes are designed to measure the copy number of the human ATM and GLI1 gene located on chromosome band 11q22.3 and 12q13.3, respectively.